Human Prehistory: The Message from Linkage Disequilibrium

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Human Prehistory: The Message from Linkage Disequilibrium

The vast amount of information being gathered about human DNA sequence variation raises the question of what these data can tell us about events in our past. A new way has been found by which patterns of linkage disequilibrium can be used to detect the effects of natural selection in human prehistory.

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Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...

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The Pattern of Linkage Disequilibrium in Livestock Genome

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ژورنال

عنوان ژورنال: Current Biology

سال: 2003

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(03)00032-0